The 2010–11 Midland Football Combination season was the 74th in the history of Midland Football Combination, a football competition in England.
| Competition: | Midland Football Combination Premier Division |
| Season: | 2010–11 |
| Winners: | Heather St John's |
| Promoted: | Heather St John's |
| Matches: | 342 |
| Total Goals: | 1149 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The Premier Division featured 18 clubs which competed in the division last season, along with one new club, promoted from Division One: