| Second and Third Division Knock-Out | |
| Year: | 2010–11 |
| Country: | Malta |
| Num Teams: | 32 |
| Dates: | 1 September 2010 – 8 May 2011 |
| Defending Champions: | Żejtun Corinthians |
| Champions: | Żejtun Corinthians |
| Runner-Up: | Rabat Ajax |
| Matches: | 55 |
| Goals: | 150 |
| Prevseason: | 2009–10 |
The 2010–11 Second and Third Division Knock-Out (known as quick Keno Second and Third Division Knock-Out for sponsorship reasons) was a knockout tournament for Maltese football clubs playing in the Second and Third Division. Played between 1 September 2010 and 8 May 2011, Żejtun Corinthians successfully defended last season's title.