| First Division Knock-Out | |
| Year: | 2010–11 |
| Num Teams: | 10 |
| Dates: | 18 September 2010 – 13 May 2011 |
| Defending Champions: | Marsaxlokk |
| Champions: | Dingli Swallows |
| Runner-Up: | Balzan Youths |
| Matches: | 23 |
| Goals: | 71 |
| Prevseason: | 2009–10 |
The 2010–11 Maltese First Division Knock-Out was a knockout tournament for Maltese football clubs playing in the First Division. The competition was held between 18 September 2010 and 13 May 2011, with the winners being Dingli Swallows.
|colspan="3" style="background:#fcc;"|7 May 2011|}
|colspan="3" style="background:#fcc;"|13 May 2011|}