| Competition: | Maltese First Division |
| Season: | 2010–11 |
| League Topscorer: | Simon Shead Mosta F.C. (11 goals) |
| Highest Scoring: | Pietà 6–1 Dingli St. George's 3–4 Balzan Balzan 4–3 Pieta |
| Matches: | 56 |
| Total Goals: | 161 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Maltese First Division (also known as 2010–11 BOV 1st Division due to sponsorship reasons) began on 23 October 2010 and ended on 1 May 2011.
Due to a in-season change regarding the league system, the third-placed team of this season will be promoted to the Maltese Premier League, along with the regular two promotees.
These teams will contest the 2010–11 season:
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Simon Shead | Mosta | 15 |
| 2 |  John Paul Muscat | Mqabba | 14 |
| 3 |  Pedrinho | Balzan Youths | 13 |
| 4 | Zach Muscat | Pietà Hotspurs | 11 |
| 5 | Glenn Bonello | St. George's | 10 |
| 6 | Quelin Refalo | Pietà Hotspurs | 8 |
| Mark Briggs | Mosta | ||
| 8 | Thiago Mazzitelli | Mqabba | 7 |
| Jonathan Luis Ruiz | St. George's | ||
 Admir Džanović | Lija Athletic |