| Competition: | Liga Nacional de Fútbol de Guatemala |
| Season: | 2010–11 |
| Winners: | Apertura: Comunicaciones (23rd title) Clausura: Comunicaciones (24th title) |
| Relegated: | USAC Xinabajul |
| Continentalcup1: | 2011–12 CONCACAF Champions League |
| Continentalcup1 Qualifiers: | Comunicaciones Municipal |
| Biggest Home Win: | Suchitepéquez 7–0 USAC (September 19) |
| Biggest Away Win: | Xinabajul 0–3 Marquense (July 24) Comunicaciones 1–4 Municipal (September 19) Malacateco 0–3 Heredia (October 31) |
| Highest Scoring: | Suchitepéquez 4–3 Marquense (September 1) Suchitepéquez 7–0 USAC (September 19) |
| Matches: | 132 |
| Total Goals: | 320 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Liga Nacional de Fútbol de Guatemala season is the 12th season in which the Apertura and Clausura season is used. The league season is divided into two tournaments, the Apertura, which is played from August to December, and the Clausura which is played from January to May.
The format for both championships are identical. Each championship will have two stages: a first stage and a playoff stage. The first stage of each championship is a double round-robin format. The teams that finishes 1 and 2 in the standings will advance to the playoffs semifinals, while the teams that finish 3–6 will enter in the quarterfinals. The winner of each quarterfinals will advance to the semifinals. The winners of the semifinals will advance to the finals, which will determine the tournament champion.
| Team | Home city | Stadium | Capacity |
|---|---|---|---|
| Comunicaciones | Guatemala | Cementos Progreso | 16,000 |
| Heredia | San José | Julian Tesucun | 8,000 |
| Juventud Retalteca | Retalhuleu | Óscar Monterroso | 8,000 |
| Malacateco | Malacatán | Santa Lucía | 7,000 |
| Marquense | San Marcos | Marquesa de la Ensenada | 10,000 |
| Mictlán | Asunción Mita | La Asunción | 3,000 |
| Municipal | Guatemala | Mateo Flores | 30,000 |
| Peñarol | Huehuetenango | Los Cuchumatanes | 5,340 |
| Suchitepéquez | Mazatenango | Carlos Salazar Hijo | 12,000 |
| Universidad San Carlos | Guatemala | Revolución USAC | 5,000 |
| Xelajú | Quetzaltenango | Mario Camposeco | 11,000 |
| Xinabajul | Huehuetenango | Los Cuchumatanes | 5,340 |
| Pos | Player | Club | Goals |
|---|---|---|---|
| 1 | Guillermo Ramírez | Municipal (Considered the award-winner for playing less minutes) | 13 |
 Henry Hernández | Heredia | 13 | |
| Andy Herron | USAC | 13 | |
| 4 | Mario Rodríguez | Municipal | 11 |
| 5 |  Israel Silva | Xelajú | 9 |
| 6 | Martín Crossa | Xelajú | 8 |
| Evandro Ferreira | Suchitepéquez | 8 | |
| Óscar Isaula | Malacateco | 8 | |
 Johnny Ruiz | Marquense | 8 | |
| 10 | Jonny Brown | Marquense | 7 |
| Orvelio Mazariegos | Peñarol | 7 | |
| Tránsito Montepeque | Comunicaciones | 7 | |
| Pos | Player | Club | Goals |
|---|---|---|---|
| 1 | Óscar Isaula | Malacateco | 7 |
| 2 | Guilherme de Paula | Peñarol | 6 |
| Israel Silva | Xelajú | 6 | |
| 4 | Mario Castellanos | Heredia | 5 |
 Fernando Gallo | Juventud Retalteca | 5 | |
| Henry Hernández | Heredia | 5 | |
| Johnny Ruiz | Marquense | 5 | |
| 8 | Mario Rodríguez | Municipal | 4 |
| 9 | Rodrigo Bengua | Mictlán | 3 |
 Carlos Kamiani Félix | USAC | 3 | |
| Evandro Ferreira | Suchitepéquez | 3 | |
| Darwin Oliva | Municipal | 3 | |