| Club: | Frosinone Calcio |
| Season: | 2010–11 |
| Manager: | Guido Carboni (until 8 January) Salvatore Campilongo (from 8 January) |
| Stadium: | Stadio Matusa |
| League: | Serie B |
| League Result: | 22nd (relegated) |
| Cup1: | Coppa Italia |
| Cup1 Result: | Third round |
| League Topscorer: | Gianluca Sansone (10)[1] |
| Pattern B1: | _frosinone1011h |
| Pattern La1: | _frosinone1011h |
| Pattern Sh1: | _frosinone1011h |
| Body1: | FFFF00 |
| Leftarm11: | FFFF00 |
| Rightarm1: | FFFF00 |
| Shorts1: | FFFF00 |
| Socks1: | FFFF00 |
| Pattern B2: | _frosinone1011a |
| Pattern La2: | _blueborder |
| Pattern Ra2: | _yellowborder |
| Body2: | FFFFFF |
| Leftarm2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | FFFFFF |
| Socks2: | FFFFFF |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 season was Frosinone Calcio's 83rd season in existence and fifth consecutive in the Serie B. They also competed in the Serie B.
See main article: 2010–11 Serie B.
See main article: 2010–11 Coppa Italia.