| Competition: | French Guiana Division d'Honneur |
| Season: | 2010–11 |
| Winners: | Matoury |
| Relegated: | Olympique Cayenne Balata Abriba |
| Continentalcup1: | Coupe de France |
| Continentalcup1 Qualifiers: | Matoury |
| Continentalcup2: | CFU Club Championship |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 French Guiana Division d'Honneur was the 38th season of the top tier of football in Guyana. The champions were US Matoury who won their third league title, and their first since 2005–06.
As winners of the 2009–10 French Guiana Championnat National, ASC Le Geldar earned a berth in the overseas bracket in the seventh round proper of the Coupe de France. Le Geldar played amateur French side, FC Martigues and lost 2–0.
See main article: 2011 CFU Club Championship.
For the 2011 edition of the CFU Club Championship, French Guiana was allowed to send two representatives to the tournament, but declined to participate.
See main article: 2010–11 CONCACAF Champions League.
As no French Guiana clubs entered in the 2010 CFU Club Championship, no teams from the Championnat National played in the Champions League.