| Competition: | Czech Women's First League |
| Season: | 2010–11 |
| Winners: | Sparta Praha (16th title) |
| Relegated: | Teplice |
| Continentalcup1: | UEFA Women's Champions League |
| Continentalcup1 Qualifiers: | Sparta Praha |
| Matches: | 72 |
| Total Goals: | 303 |
| League Topscorer: | Petra Divišová |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Czech Women's First League was the 18th season of the Czech Republic's top-tier football league for women.
Sparta Praha won the championship. Teplice was relegated.[1]
Eighth place Pardubice played a two-legged play-off against Slovan Liberec. Liberec had won the second league promotion play-off against Jihlava 6–0 on aggregate.[2] Pardubice then won the relegation play-off 3–2 on aggregate and remained in the first division.