The 2010–11 Cuban National Series was the 50th edition of the tournament. It began on November 28 with a game between Villa Clara and Industriales, with Villa Clara winning, 6-5. The All-Star Game was played on February 6, 2011. The regular season finished on March 24.
| Team | G | W | L | Pct. | GB | Home | Road | |
|---|---|---|---|---|---|---|---|---|
| 90 | 59 | 31 | .656 | - | 31-14 | 28-17 | ||
| 89 | 50 | 39 | .562 | 28-16 | 22-23 | |||
| 90 | 49 | 41 | .544 | 10 | 32-13 | 17-28 | ||
| 90 | 49 | 41 | .544 | 10 | 28-17 | 21-24 | ||
| 90 | 44 | 46 | .489 | 15 | 24-21 | 20-25 | ||
| 90 | 38 | 52 | .422 | 21 | 21-24 | 17-28 | ||
| 89 | 34 | 55 | .382 | 18-26 | 16-29 | |||
| 90 | 28 | 62 | .311 | 31 | 13-32 | 15-30 |
| Team | G | W | L | Pct. | GB | Home | Road | |
|---|---|---|---|---|---|---|---|---|
| 90 | 55 | 35 | .611 | - | 33-12 | 22-23 | ||
| 90 | 53 | 37 | .589 | 2 | 30-15 | 23-22 | ||
| 90 | 51 | 39 | .567 | 4 | 30-15 | 21-24 | ||
| 89 | 50 | 39 | .562 | 27-18 | 23-21 | |||
| 90 | 45 | 45 | .500 | 10 | 24-21 | 21-24 | ||
| 90 | 43 | 47 | .478 | 12 | 24-21 | 19-26 | ||
| 90 | 41 | 49 | .456 | 14 | 21-24 | 20-25 | ||
| 89 | 29 | 60 | .326 | 17-28 | 12-32 |
| Total | |||
| José Dariel Abreu (CFG) | .453 | ||
| Dainer Moreira (GTM) | 130 | ||
| Yoenis Céspedes (GRA) | 89 | ||
| Yoenis Céspedes (GRA) Jose D. Abreu (CFG) | 33 | ||
| Yoenis Céspedes (GRA) | 99 |
| Total | |||
| Freddy Asiel Álvarez (VCL) | 1.89 | ||
| Norberto González (CFG) | 13 | ||
| Duniel Ibarra (CFG) | 27 | ||
| Wilber Pérez (IJV) | 97 | ||
| Yoelkis Cruz (LTU) |