| Tourney Name: | Copa Castilla y León |
| Year: | 2010–11 |
| Country: | Spain |
| Dates: | From July 25, 2010 to June 7, 2011 |
| Num Teams: | 12 |
| Venues: | 10 |
| Cities: | 10 |
| Matches: | 15 |
| Goals: | 32 |
| Champion Other: | SD Ponferradina |
| Count: | 1 |
| Second Other: | UD Salamanca |
| Top Scorer: | Miguel Linares (3) |
| Prevseason: | 2009–10 |
| Nextseason: | 2011 |
The Castilla y León Cup 2010–11 (Spanish: Copa Castilla y León 2010–11) is the second edition of this football trophy in its renewed version. It was organized before the final match of the previous cup, twice postponed because of Liga BBVA and Liga Adelante matchdays schedules.
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| Palencia (Q) | 2 | 2 | 0 | 0 | 4 | 1 | +3 | 6 |
| Real Valladolid | 2 | 1 | 0 | 1 | 1 | 2 | - 1 | 3 |
| Arandina | 2 | 0 | 0 | 2 | 1 | 3 | - 2 | 0 |
| Burgos (Q) | 2 | 1 | 1 | 0 | 3 | 1 | +2 | 4 |
| Numancia | 2 | 1 | 1 | 0 | 3 | 2 | +1 | 4 |
| Mirandés | 2 | 0 | 0 | 2 | 1 | 4 | - 3 | 0 |
| Ponferradina (Q) | 2 | 2 | 0 | 0 | 4 | 1 | +3 | 6 |
| Cultural Leonesa | 2 | 0 | 1 | 1 | 0 | 1 | - 1 | 1 |
| Zamora | 2 | 0 | 1 | 1 | 1 | 3 | - 2 | 1 |
| UD Salamanca (Q) | 2 | 1 | 1 | 0 | 6 | 1 | +5 | 4 |
| Guijuelo | 2 | 1 | 1 | 0 | 3 | 1 | +2 | 4 |
| Real Ávila | 2 | 0 | 0 | 2 | 0 | 7 | - 7 | 0 |
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The final match was originally scheduled for the festivity of Castilla y León (23 April). However, the match was postponed until both teams were available because the original date was reserved to one Liga Adelante matchday. After finishing the league season, with both finalists relegated to Segunda División B, the final was played at El Toralín on 7 June.