| Competition: | Campionato Sammarinese di Calcio |
| Season: | 2010-11 |
| Winners: | Tre Fiori (7th title) |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Tre Fiori |
| Continentalcup2: | Europa League |
| Continentalcup2 Qualifiers: | Juvenes/Dogana Tre Penne |
| Biggest Home Win: | Folgore 5–0 S.S. Cosmos Faetano 5-0 Cailungo[1] |
| Biggest Away Win: | Folgore 0–5 Murata |
| Highest Scoring: | La Fiorita 6–3 San Giovanni |
| Matches: | 155 |
| Total Goals: | 437 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Campionato Sammarinese di Calcio season was the twenty-sixth since its establishment. The season began with the first regular season games on 17 September 2010[2] and ended with the play-off final in May 2011. Tre Fiori are the league champions, having won their seventh Sammarinese championship and third-in-a-row last season.
Because there is no promotion or relegation in the league, the same 15 teams who competed in the league last season competed in the league this season.
The teams do not have grounds of their own due to restricted space in San Marino. Each match was randomly assigned to one of the following grounds:
All teams played twice against the teams within their own group and once against the teams from the other group. This meant that the clubs in Group A played 20 matches each while the clubs in the Group B played 21 matches each during the regular season.
The playoff was held in a double-eliminination format. Both group winners earned byes in the first and second round.
All times CEST
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Libertas were eliminated.
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La Fiorita were eliminated.
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Pennarossa were eliminated.
Cosmos were eliminated.
The winner of the final qualifies for the first qualifying round of the 2011–12 UEFA Champions League, while the runner-up qualifies for the first qualifying round of the 2011–12 UEFA Europa League.
Including matches played on 17 April 2011; Source: Soccerway
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Marco Fantini | Juvenes/Dogana | 12 |
| José Hirsch | Virtus | 12 | |
 Alessandro Giunta | Tre Fiori | 12 | |
| Francesco Viroli | Faetano | 12 | |
| Roberto Gatti | Murata | 12 | |
| 6 | Marco Ugolini | San Giovanni | 11 |
| 7 | Daniele Pignieri | Tre Penne | 10 |
| 8 | Simon Parma | La Fiorita | 9 |
| Sossio Aruta | Tre Fiori | 9 | |
 Elton Shabani | Virtus | 9 |