The Liga ABF 2009–10 was the 53rd season of women's handball top flight in Spain since its establishment, running from 12 September 2010 to 15 May 2010. Fourteen teams took part in the championship, with CB Castro Urdiales and CBM Murcia replacing relegated teams CB Monóvar and CB Zuazo.
Defending champion SD Itxako won its second title,[1] while EHF Cup runner-up CBF Elda was second and BM Sagunto, Mar Alicante and CB León also qualified for EHF's competitions.[2] BM Gijón and CB Ribarroja were relegated, with the latter (CB Amadeo Tortajada's successor) being disbanded following the end of the season.
| width=20 | width=150 | Team | width=20 | Pld | width=20 | W | width=20 | D | width=20 | L | width=30 | GF | width=30 | GA | width=30 | Pt | width=30 | 2010 | width=300 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Itxako | 26 | 22 | 2 | 2 | 781 | 536 | 46 | QF for the 2011 Champions League | ||||||||||||
| 2 | 26 | 20 | 3 | 3 | 779 | 608 | 43 | 1 | QF for the 2011 Champions League's qual. stage | ||||||||||||
| 3 | 26 | 19 | 1 | 6 | 799 | 668 | 39 | 1 | QF for the 2011 EHF Cup | ||||||||||||
| 4 | 26 | 17 | 2 | 7 | 765 | 641 | 36 | 1 | QF for the 2011 Cup Winners' Cup | ||||||||||||
| 5 | 26 | 15 | 1 | 10 | 641 | 619 | 31 | 3 | QF for the 2011 EHF Cup | ||||||||||||
| 6 | 26 | 14 | 1 | 11 | 739 | 693 | 29 | 2 | |||||||||||||
| 7 | 26 | 11 | 2 | 13 | 682 | 673 | 24 | 1 | |||||||||||||
| 8 | 26 | 11 | 2 | 13 | 631 | 676 | 24 | 1 | |||||||||||||
| 9 | 26 | 11 | 1 | 14 | 660 | 663 | 23 | (N) | |||||||||||||
| 10 | 26 | 10 | 3 | 13 | 645 | 703 | 23 | ||||||||||||||
| 11 | 26 | 8 | 3 | 15 | 635 | 706 | 19 | ||||||||||||||
| 12 | 26 | 7 | 1 | 18 | 610 | 753 | 15 | (N) | |||||||||||||
| 13 | 26 | 4 | 4 | 18 | 584 | 672 | 12 | 4 | Relegated to Division de Honor Plata | ||||||||||||
| 14 | 26 | 0 | 0 | 26 | 517 | 856 | 0 | (N) | Disbanded |