| Champ: |  Marcel Granollers Pujol |
| Runner: |  James Blake |
| Score: | 6–4, 1–6, 7–5 |
| Draw: | 32 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: 2008 U.S. Men's Clay Court Championships.
Ivo Karlović was the defending champion, but chose not to participate that year.
Seventh-seeded Marcel Granollers Pujol won in the final 6–4, 1–6, 7–5, against James Blake.