| Year: | 2008 |
| Team: | Sioux Falls Cougars |
| Sport: | football |
| Conference: | Great Plains Athletic Conference |
| Short Conf: | GPAC |
| Record: | 14–0 |
| Conf Record: | 10–0 |
| Head Coach: | Kalen DeBoer |
| Hc Year: | 4th |
| Off Coach: | Chuck Morrell |
| Oc Year: | 10th |
| Def Coach: | Jon Anderson |
| Dc Year: | 7th |
| Champion: | NAIA national champion GPAC champion |
| Bowl: | NAIA National Championship Game |
| Bowl Result: | W 23–7 vs. |
The 2008 Sioux Falls Cougars football team represented the University of Sioux Falls in the 2008 NAIA football season. The Cougars captured the 2008 NAIA Football National Championship with a 23–7 victory over the top-ranked . The team also won the Great Plains Athletic Conference championship with a perfect 10–0 record. This was the school's third NAIA national championship (1996, 2006) and second in three years. The team was coached by Kalen DeBoer.
| Game | Date | Opponent | Result | Cougars | Opponents | Record | |
| 1 | 9/6 | Win | 35 | 0 | 1 - 0 (1 - 0) | ||
| 2 | 9/13 | Win | 70 | 0 | 2 - 0 (2 - 0) | ||
| 3 | 9/20 | Win | 30 | 17 | 3 - 0 (3 - 0) | ||
| 4 | 9/27 | Win | 47 | 0 | 4 - 0 (4 - 0) | ||
| 5 | 10/4 | Win | 37 | 7 | 5 - 0 (5 - 0) | ||
| 6 | 10/11 | Briar Cliff | Win | 42 | 0 | 6 - 0 (6 - 0) | |
| 7 | 10/25 | @ Dakota Wesleyan | Win | 38 | 0 | 7 - 0 (7 - 0) | |
| 8 | 11/1 | Win | 19 | 0 | 8 - 0 (8 - 0) | ||
| 9 | 11/8 | Win | 34 | 2 | 9 - 0 (9 - 0) | ||
| 10 | 11/15 | Morningside | Win | 34 | 31 | 10 - 0 (10 - 0) | |
| 11 | 11/22 | Win | 28 | 0 | 11 - 0 (10 - 0) | ||
| 12 | 11/29 | Win | 50 | 13 | 12 - 0 (10 - 0) | ||
| 13 | 12/6 | Win | 24 | 6 | 13 - 0 (10 - 0) | ||
| 14 | 12/20 | Win | 23 | 7 | 14 - 0 (10 - 0) |
USF would start the season ranked #2 and would stay at that spot through the championship series.