| Flag Image: | Flag of San Juan, Puerto Rico.svg |
| Country: | Puerto Rico |
| Type: | presidential |
| Previous Election: | 2004 San Juan, Puerto Rico, mayoral election |
| Previous Year: | 2004 |
| Next Election: | 2012 San Juan, Puerto Rico, mayoral election |
| Next Year: | 2012 |
| Election Date: | November 4, 2008 |
| Image1: | Jorge Santini Padilla, Mayor of San Juan, Puerto Rico (cropped) (a).jpg |
| Nominee1: | Jorge Santini |
| Party1: | New Progressive Party (Puerto Rico) |
| Popular Vote1: | 96,444 |
| Percentage1: | 51.96% |
| Nominee2: | Ferdinand Pérez Román |
| Party2: | Popular Democratic Party (Puerto Rico) |
| Popular Vote2: | 84,109 |
| Percentage2: | 45.31% |
| Mayor | |
| Before Election: | Jorge Santini |
| Before Party: | New Progressive Party (Puerto Rico) |
| After Election: | Jorge Santini |
| After Party: | New Progressive Party (Puerto Rico) |
San Juan, Puerto Rico, held an election for mayor on November 4, 2008. Among other elections, it was held concurrently with the 2008 Puerto Rico gubernatorial election. It saw the reelection incumbent mayor Jorge Santini, a member of the New Progressive Party, to a third consecutive term.