| Champ: |  Steve Darcis |
| Runner: |  Robin Söderling |
| Score: | 6–3, 7–6(7–5) |
| Draw: | 32 (4 / 3) |
| Seeds: | 8 |
See main article: 2008 Regions Morgan Keegan Championships and the Cellular South Cup.
Tommy Haas was the defending champion, but lost in the second round to Benjamin Becker.
Steve Darcis won in the final 6–3, 7–6(7–5), against Robin Söderling.