See main article: 2008 Regions Morgan Keegan Championships and the Cellular South Cup.
Eric Butorac and Jamie Murray were the defending champions. They were both present but did not compete together.
Butorac partnered with Todd Perry, but lost in the first round to Scott Lipsky and David Martin.
Murray partnered with Max Mirnyi, but lost in the first round to Thomas Johansson and Robert Lindstedt.
Mahesh Bhupathi and Mark Knowles won in the final 7–6(7–5), 6–2, against Sanchai Ratiwatana and Sonchat Ratiwatana.