| Champ: | Marin Čilić |
| Runner: |  Mardy Fish |
| Score: | 6–4, 4–6, 6–2 |
See main article: 2008 Pilot Pen Tennis.
James Blake was the defending champion, but chose not to participate that year.
Marin Čilić won in the final 6–4, 4–6, 6–2, against Mardy Fish.
All seeds receive a bye into the second round.