| Year: | 2008 |
| Team: | Nicholls State Colonels |
| Sport: | football |
| Conference: | Southland Conference |
| Short Conf: | Southland |
| Record: | 3–6 |
| Conf Record: | 3–4 |
| Head Coach: | Jay Thomas |
| Hc Year: | 5th |
| Off Coach: | H. T. Kinney |
| Oc Year: | 5th |
| Off Scheme: | Spread option |
| Def Coach: | Steve Ellis |
| Dc Year: | 3rd |
| Def Scheme: | Multiple 4–3 |
| Stadium: | John L. Guidry Stadium |
The 2008 Nicholls State Colonels football team represented Nicholls State University as a member of the Southland Conference during the 2008 NCAA Division I FCS football season. Led by fifth-year head Jay Thomas, the Colonels compiled an overall record of 3–6 with a mark of 3–4 in conference play, placing fifth in the Southland. Nicholls State played home games at John L. Guidry Stadium in Thibodaux, Louisiana.