| Date: | July 21 – July 27 |
| Edition: | 14th |
| Location: | Lexington, Kentucky, United States |
| Champms: |  Somdev Devvarman |
| Champmd: |  Alessandro da Col / Andrea Stoppini |
| Champws: |  Melanie Oudin |
| Champwd: | Chan Chin-wei / Kimberly Couts |
The 2008 Fifth Third Bank Tennis Championships was a professional tennis tournament played on Hard court. It was a fourteenth edition of the tournament which was part of the 2008 ATP Challenger Series. It took place in Lexington, Kentucky, United States between 21 and 27 July 2008.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
 Israel | Dudi Sela | 78 | 1 | |
| Bobby Reynolds | 90 | 2 | ||
| Robert Kendrick | 123 | 3 | ||
| Kristian Pless | 128 | 4 | ||
| Amer Delić | 144 | 5 | ||
| Israel | Harel Levy | 157 | 6 | |
| Brendan Evans | 174 | 7 | ||
| Kevin Kim | 182 | 8 |
The following players received wildcards into the singles main draw:
Chase Buchanan Amer Delić Bryan Koniecko Rhyne WilliamsThe following players received entry from the qualifying draw:
Somdev Devvarman Alberto Francis Justin O'Neal Rylan RizzaThe following players received entry by special exempt:
See main article: 2008 Fifth Third Bank Tennis Championships – Men's singles.
Somdev Devvarman def. Robert Kendrick 6–3, 6–3See main article: 2008 Fifth Third Bank Tennis Championships – Women's singles.
Melanie Oudin def. Carly Gullickson 6–4, 6–2See main article: 2008 Fifth Third Bank Tennis Championships – Men's doubles.
Alessandro da Col / Andrea Stoppini def. 
Olivier Charroin / 
Érik Chvojka 6–2, 2–6, [10–8]See main article: 2008 Fifth Third Bank Tennis Championships – Women's doubles.
Kimberly Couts def. Lindsay Lee-Waters / Melanie Oudin 2–6, 6–3, [10–8]