See main article: 2008 Regions Morgan Keegan Championships and the Cellular South Cup.
Nicole Pratt and Bryanne Stewart were the defending champions, but Pratt chose not to participate, and only Stewart competed that year.
Stewart partnered with Alina Jidkova, but lost in the first round to Maret Ani and Séverine Brémond.
Lindsay Davenport and Lisa Raymond won in the final 6–3, 6–1, against Angela Haynes and Mashona Washington.
Bethanie Mattek / 
Renata Voráčová (quarterfinals)
Alina Jidkova / 
Bryanne Stewart (first round) Lindsay Davenport / Lisa Raymond (champions)
İpek Şenoğlu (first round)