See main article: 2008 Bank of the West Classic. The defending champions lost separately in the first round. Sania Mirza partnered with Anna Chakvetadze and lost to Eva Hrdinová and Vladimíra Uhlířová. Shahar Pe'er teamed with Gisela Dulko to lose to Ayumi Morita and Ai Sugiyama.
Cara Black and Liezel Huber won the final 6–4, 6–3, over Elena Vesnina and Vera Zvonareva.