See main article: 2008 Artois Championships.
Rafael Nadal defeated Novak Djokovic in the final, 7–6(8–6), 7–5 to win the singles tennis title at the 2008 Queen's Club Championships.
Andy Roddick was the defending champion, but lost in the semifinals to Nadal. This marked the first time since 1999 that neither Lleyton Hewitt nor Roddick won the title.
The top eight seeds receive a bye into the second round.