The women's 4 x 100 metres relay at the 2008 African Championships in Athletics was held on May 1–2.
| width=200 valign=top | Endurance Ojokolo Gloria Kemasuode Susan Akene Oludamola Osayomi | width=200 valign=top | Gifty Addy Elizabeth Amolofo Esther Dankwah Vida Anim | width=200 valign=top | Tsholofelo Thipe Isabel Le Roux Christine Ras Geraldine Pillay |
Qualification: First 3 teams of each heat (Q) plus the next 2 fastest (q) qualified for the final.
| Rank | Heat | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 1 | 2 | 44.17 | Q | |||
| 2 | 2 | 44.25 | Q | |||
| 3 | 2 | 44.63 | Q | |||
| 4 | 2 | 45.32 | q | |||
| 5 | 1 | 45.70 | Q | |||
| 6 | 2 | 46.37 | q | |||
| 7 | 1 | 46.44 | Q | |||
| 8 | 1 | 47.04 | Q | |||
| 9 | 1 | 48.88 | NR |
| Rank | Lane | Nation | Competitors | Time | Notes | |
|---|---|---|---|---|---|---|
| 5 | 43.79 | |||||
| 4 | 44.12 | |||||
| 8 | 44.28 | |||||
| 4 | 3 | 45.63 | ||||
| 5 | 6 | 46.64 | ||||
| 6 | 7 | 47.41 | ||||
| 7 | 1 | 50.37 | ||||
| 2 |