The women's 4 x 400 metres relay at the 2008 African Championships in Athletics was held on May 3–4.
| width=200 valign=top | Oluoma Nwoke Folashade Abugan Endurance Abinuwa Joy Eze Ngozi Nwokocha | width=200 valign=top | Florence Wasike Charity Wandia Joy Sakari Pamela Jelimo Elizabeth Muthuka | width=200 valign=top | Fatou Diabaye Maty Salame Ndèye Fatou Soumah Mame Fatou Faye |
* Athletes who participated in heats only.
Qualification: First 3 teams of each heat (Q) plus the next 2 fastest (q) qualified for the final.
| Rank | Heat | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 1 | 2 | 3:34.90 | Q | |||
| 2 | 1 | 3:41.40 | Q | |||
| 3 | 2 | 3:42.24 | Q | |||
| 4 | 1 | 3:42.24 | Q | |||
| 5 | 2 | 3:46.39 | Q | |||
| 6 | 1 | 3:47.27 | Q | |||
| 7 | 1 | 3:48.44 | q | |||
| 8 | 2 | 3:50.14 | q | |||
| 1 | ||||||
| 2 |
| Rank | Nation | Competitors | Time | Notes | |
|---|---|---|---|---|---|
| 3:30.07 | |||||
| 3:37.67 | |||||
| 3:38.42 | |||||
| 4 | 3:41.54 | ||||
| 5 | 3:42.36 | ||||
| 6 | 3:45.07 | ||||
| 7 | 3:51.68 | ||||