The men's 4 x 400 metres relay at the 2008 African Championships in Athletics was held on May 3–4.
| width=200 valign=top | Pieter Smith Ockert Cilliers Sibusiso Sishi L.J. van Zyl Ofentse Mogawane | width=200 valign=top | Rabah Yousif Nagmeldin Ali Abubakr Ismail Ahmed Ismail Abubaker Kaki Awad El Karim Makki | width=200 valign=top | Mamadou Kasse Hanne El Hadj Seth Mbow Mamadou Gueye Nouha Badji |
* Athletes who participated in heats only.
Qualification: First 3 teams of each heat (Q) plus the next 2 fastest (q) qualified for the final.
| Rank | Heat | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 1 | 2 | 3:05.57 | Q | |||
| 2 | 2 | 3:06.51 | Q | |||
| 3 | 2 | 3:07.48 | Q | |||
| 4 | 2 | 3:08.18 | q | |||
| 5 | 1 | 3:08.35 | Q | |||
| 6 | 2 | 3:08.44 | q | |||
| 7 | 1 | 3:08.51 | Q | |||
| 8 | 1 | 3:08.88 | Q | |||
| 9 | 2 | 3:13.81 | ||||
| 10 | 1 | 3:23.60 | ||||
| 11 | 1 | 3:28.43 | ||||
| 12 | 2 | 3:31.27 | ||||
| 13 | 1 | 3:34.78 | ||||
| 1 | ||||||
| 2 |
| Rank | Nation | Competitors | Time | Notes | |
|---|---|---|---|---|---|
| 3:03.58 | |||||
| 3:04.00 | |||||
| 3:05.93 | |||||
| 4 | 3:06.54 | ||||
| 5 | 3:06.94 | ||||
| 6 | 3:06.95 | ||||
| 7 | 3:07.60 | ||||
| 8 | 3:07.71 |