See main article: 2008 ABN AMRO World Tennis Tournament.
Mikhail Youzhny was the defending champion, but lost in the first round to Janko Tipsarević.
None of the 8 seeded players reached quarter-finals. Michaël Llodra won his only ATP 500 singles final 6–7(3–7), 6–3, 7–6(7–4), against Robin Söderling.