| Second and Third Division Knock-Out | |
| Year: | 2008–09 |
| Num Teams: | 31 |
| Dates: | 3 September 2008 – 29 May 2009 |
| Defending Champions: | Melita |
| Champions: | Melita |
| Runner-Up: | St. Venera Lightnings |
| Matches: | 52 |
| Goals: | 163 |
| Prevseason: | 2007–08 |
| Nextseason: | 2009–10 |
The 2008–09 Second and Third Division Knock-Out (known as quick Keno Second and Third Division Knock-Out for sponsorship reasons) was a knockout tournament for Maltese football clubs playing in the Second and Third Division. The winners were Melita which successfully defended this title from their win in the previous season.