| Champ: | Ivo Karlović |
| Runner: |  Mariano Zabaleta |
| Score: | 6–4, 6–1 |
| Draw: | 32 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: 2007 U.S. Men's Clay Court Championships.
Unseeded Ivo Karlović defeated Mariano Zabaleta 6–4, 6–1, to win the 2007 U.S. Men's Clay Court Championships singles event.
Andy Murray entered the ATP Top 10 for the first time due to Tommy Haas failing to defend his previous year points.