| Champ: |  Rafael Nadal |
| Runner: |  Novak Djokovic |
| Score: | 6–2, 7–5 |
| Draw: | 96 |
| Seeds: | 32 |
| Main Name: | Indian Wells Masters |
Rafael Nadal defeated Novak Djokovic in the final, 6–2, 7–5 to win the men's singles tennis title at the 2007 Indian Wells Masters. He did not lose a single set in the entire tournament. By reaching the final, Djokovic entered the world's top 10 in rankings for the first time in his career.
Roger Federer was the three-time defending champion, but lost in the second round to Guillermo Cañas.
All thirty-two seeds received a bye into the second round.