| Champ: |  Rafael Nadal |
| Runner: |  Novak Djokovic |
| Score: | 6–2, 7–5 |
| Draw: | 96 |
| Seeds: | 32 |
| Main Name: | Indian Wells Masters |
See main article: 2007 Indian Wells Masters.
Rafael Nadal defeated Novak Djokovic in the final, 6–2, 7–5 to win the men's singles tennis title at the 2007 Indian Wells Masters. He did not lose a single set in the entire tournament. By reaching the final, Djokovic entered the world's top 10 in rankings for the first time in his career.
Roger Federer was the three-time defending champion, but lost in the second round to Guillermo Cañas.
All thirty-two seeds received a bye into the second round.