| Tourney Name: | CAF Confederation Cup |
| Year: | 2007 |
| Other Titles: | Confederation of African Football Confederation Cup |
| Size: | 130px |
| Dates: | 28 January – 24 November |
| Num Teams: | 58 |
| Champion Other: |  CS Sfaxien |
| Count: | 1 |
| Second Other: | Al-Merrikh |
| Matches: | 114 |
| Goals: | 309 |
| Top Scorer: |  Trésor Mputu (11 goals) |
| Prevseason: | 2006 |
| Nextseason: | 2008 |
The 2007 CAF Confederation Cup was the fourth edition of the CAF Confederation Cup. Its schedule began with the preliminary round (home-and-away ties) in late January and mid-February with the second round in March and the third round in April.
All rounds have been drawn.
1st legs played 26–28 January 2007 and 2nd legs played 9–11 February 2007.
|}1 The tie was played over one leg by mutual consent due to civil unrest in Guinea.
1st legs played 2–4 March 2007 and 2nd legs played 16–18 March 2007.
|}
1 Tema Youth were disqualified for not showing up to the first leg.
1st legs played 6–8 April 2007 and 2nd legs played 20–22 April 2007.
|}1 Benfica de Luanda were ejected from the competition for fielding an ineligible player.
The 8 winners of the round of 16 play the losers of the round of 16 of the Champions League for 8 places in the group stage.
1st legs played 4–6 May 2007 and 2nd legs played 18–20 May 2007.
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See main article: 2007 CAF Confederation Cup group stage. The Group Stage matches were played between August and October 2007.
CS Sfaxien won 5–2 on aggregate.
The top scorers from the 2007 CAF Confederation Cup are as follows:
| Rank | Name | Team | Goals |
|---|---|---|---|
| 1 | Trésor Mputu | TP Mazembe | 11 |
| 2 |  Blaise Kouassi | CS Sfaxien | 10 |
| 3 | Wilfried Bony | Issia Wazi | 6 |
| Endurance Idahor | Al-Merrikh | 6 | |
| Faisal Agab | Al-Merrikh | 6 | |
| Lelo Mbele | CS Sfaxien | 6 | |
| 7 |  Omar Gamal | Ismaily | 4 |
| Bola Bello | Dolphins | 4 | |
| Douaou Bakari | EGS Gafsa | 4 |