| Champ: |  Maria Sharapova |
| Runner: | Patty Schnyder |
| Score: | 6–2, 3–6, 6–0 |
| Draw: | 56 |
| Seeds: | 16 |
| Type: | singles doubles |
| After Name: | Mercury Insurance Open |
| After Year: | 2010 |
See main article: 2007 Acura Classic.
Defending champion Maria Sharapova defeated Patty Schnyder in the final, 6–2, 3–6, 6–0 to win the singles tennis title at the 2007 Southern California Open.
The top 8 seeds received a bye into the second round.