The 2006 WNBA season was the ninth for the Washington Mystics. The Mystics reached the playoffs, but they were later swept in the opening round to the Connecticut Sun.
| Round | Pick | Player | Nationality | School/Club Team | |
| 1 | 8 | Tamara James (G/F) | Miami (FL) | ||
| 2 | 19 | Nikki Blue (G) | UCLA | ||
| 3 | 33 | Miriam Sy (C) | Oklahoma City |
| Date | Opponent | Score | Result | Record | |
| May 23 | 95-60 | Win | 1-0 | ||
| May 25 | 63-73 | Loss | 1-1 | ||
| May 27 | 90-75 | Win | 2-1 | ||
| June 3 | 92-68 | Win | 3-1 | ||
| June 6 | 93-79 | Win | 4-1 | ||
| June 7 | 70-83 | Loss | 4-2 | ||
| June 11 | 71-85 | Loss | 4-3 | ||
| June 13 | 87-70 | Win | 5-3 | ||
| June 15 | 96-77 | Win | 6-3 | ||
| June 17 | 88-70 | Win | 7-3 | ||
| June 21 | 66-72 | Loss | 7-4 | ||
| June 24 | 86-92 | Loss | 7-5 | ||
| June 25 | 87-80 | Win | 8-5 | ||
| June 27 | 67-74 | Loss | 8-6 | ||
| June 29 | 76-83 | Loss | 8-7 | ||
| July 1 | 75-80 | Loss | 8-8 | ||
| July 2 | 81-78 | Win | 9-8 | ||
| July 5 | 74-84 | Loss | 9-9 | ||
| July 7 | 60-73 | Loss | 9-10 | ||
| July 9 | 89-83 | Win | 10-10 | ||
| July 16 | 83-76 | Win | 11-10 | ||
| July 19 | 83-96 | Loss | 11-11 | ||
| July 21 | 80-77 | Win | 12-11 | ||
| July 23 | 71-73 | Loss | 12-12 | ||
| July 25 | 73-86 | Loss | 12-13 | ||
| July 27 | 92-74 | Win | 13-13 | ||
| July 29 | 74-67 | Win | 14-13 | ||
| July 30 | 78-73 | Win | 15-13 | ||
| August 1 | 84-74 | Win | 16-13 | ||
| August 3 | 78-86 | Loss | 16-14 | ||
| August 5 | 95-99 (OT) | Loss | 16-15 | ||
| August 8 | 91-79 | Win | 17-15 | ||
| August 11 | 78-66 | Win | 18-15 | ||
| August 13 | 81-93 | Loss | 18-16 |
| Game | Date | Opponent | Score | Result | Record | |
| Eastern Conference Semifinals | ||||||
| 1 | August 18 | 61-76 | Loss | 0-1 | ||
| 2 | August 20 | 65-68 | Loss | 0-2 | ||
| Player | GP | REB | AST | STL | BLK | PTS | |
| Alana Beard | 32 | 149 | 98 | 59 | 25 | 614 | |
| Chasity Melvin | 34 | 224 | 45 | 34 | 26 | 405 | |
| 34 | 89 | 183 | 44 | 11 | 364 | ||
| DeLisha Milton-Jones | 23 | 112 | 48 | 35 | 17 | 335 | |
| Nakia Sanford | 34 | 203 | 36 | 28 | 21 | 301 | |
| Coco Miller | 34 | 91 | 59 | 34 | 4 | 206 | |
| Crystal Robinson | 27 | 70 | 49 | 33 | 0 | 199 | |
| Latasha Byears | 26 | 87 | 10 | 12 | 2 | 112 | |
| Laurie Koehn | 32 | 12 | 8 | 2 | 2 | 71 | |
| Tamara James | 21 | 16 | 3 | 4 | 2 | 57 | |
| Nikki Blue | 24 | 20 | 36 | 18 | 0 | 54 | |
| Zane Teilane | 16 | 27 | 1 | 3 | 3 | 29 |