| Election Name: | 2006 United States Senate election in Mississippi |
| Country: | Mississippi |
| Flag Image: | Flag of Mississippi (2001–2020).svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 2000 United States Senate election in Mississippi |
| Previous Year: | 2000 |
| Next Election: | 2008 United States Senate special election in Mississippi |
| Next Year: | 2008 (special) |
| Election Date: | November 7, 2006 |
| Image1: | Trent Lott official photo 2007 (cropped).jpg |
| Nominee1: | Trent Lott |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 388,399 |
| Percentage1: | 63.58% |
| Nominee2: | Erik R. Fleming |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 213,000 |
| Percentage2: | 34.87% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | Trent Lott |
| Before Party: | Republican Party (United States) |
| After Election: | Trent Lott |
| After Party: | Republican Party (United States) |
The 2006 United States Senate election in Mississippi was held November 7, 2006. Incumbent Republican Trent Lott won re-election to a fourth term.
Lott ran for re-election without facing any opposition in his party's primary. While it had been speculated that Lott might retire after his home was destroyed in Hurricane Katrina, he instead chose to run for re-election. Fleming is an African American, which represents 37% of the state's population. However, no African American has ever been elected to statewide office. The last black U.S. Senator was Hiram Revels, who was appointed and took office in 1870. Fleming got little help from the DSCC, which only donated $15,000 to his campaign.[1]
| Source | Ranking | As of | ||
|---|---|---|---|---|
| align=left | The Cook Political Report[2] | November 6, 2006 | ||
| align=left | Sabato's Crystal Ball[3] | November 6, 2006 | ||
| align=left | Rothenberg Political Report[4] | November 6, 2006 | ||
| align=left | Real Clear Politics[5] | November 6, 2006 |