See main article: 2006 US Open (tennis).
Two-time defending champion Roger Federer defeated Andy Roddick in the final, 6–2, 4–6, 7–5, 6–1 to win the men's singles tennis title at the 2006 US Open. It was his third US Open title and ninth major title overall. Federer became the sixth man (after Jack Crawford, Don Budge, Frank Sedgman, Lew Hoad and Rod Laver) to reach all four major finals in one calendar year, the second to do so in the Open Era, and the first to do so since Laver in 1969. Also, he reached a record-equaling 10th consecutive major semifinal (streak starting at the 2004 Wimbledon Championships), matching Laver and Ivan Lendl.
This tournament marked the final professional appearance of eight-time major champion Andre Agassi. He was defeated by Benjamin Becker in the third round. Future champion Juan Martín del Potro made his first appearance in the main draw of the US Open, losing to Alejandro Falla in the first round. This was also the first major in which future world No. 1s Novak Djokovic and Andy Murray were seeded, at 20th and 17th, respectively.
The seeded players are listed below. Players are listed with the round in which they exited.
See main article: 2006 US Open – Men's singles qualifying.