| Year: | 2006 |
| Team: | Tennessee State Tigers |
| Sport: | football |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 6–5 |
| Conf Record: | 5–2 |
| Head Coach: | James Webster |
| Hc Year: | 2nd |
| Off Coach: | Fred Kaiss |
| Oc Year: | 1st |
| Stadium: | LP Field |
The 2006 Tennessee State Tigers football team represented Tennessee State University as a member of the Ohio Valley Conference (OVC) during the 2006 NCAA Division I FCS football season. Led by second-year head coach James Webster, the Tigers compiled an overall record of 6–5, with a conference record of 5–2, and finished third in the OVC.