| Year: | 2006 |
| Team: | Southern Miss Golden Eagles |
| Sport: | football |
| Conference: | Conference USA |
| Short Conf: | C-USA |
| Record: | 9–5 |
| Conf Record: | 6–2 |
| Head Coach: | Jeff Bower |
| Hc Year: | 17th |
| Off Coach: | Jay Johnson |
| Oc Year: | 2nd |
| Off Scheme: | Multiple |
| Def Coach: | Jay Hopson |
| Dc Year: | 2nd |
| Def Scheme: | 4–3 |
| Stadium: | M. M. Roberts Stadium |
| Champion: | C-USA East Division champion GMAC Bowl champion |
| Bowl: | GMAC Bowl |
| Bowl Result: | W 28–7 vs. Ohio |
| Conf Champ: | C-USA Championship |
| Conf Champ Result: | L 20–34 vs. Houston |
The 2006 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2006 NCAA Division I FBS football season. The Golden Eagles were led by head coach Jeff Bower and played their home games at M. M. Roberts Stadium. They were a member of the East Division of Conference USA.