| Year Game Played: | 2006 |
| Game Name: | PapaJohns.com Bowl |
| Football Season: | 2006 |
| Visitor Name Short: | South Florida |
| Visitor Nickname: | Bulls |
| Visitor School: | University of South Florida |
| Home Name Short: | East Carolina |
| Home Nickname: | Pirates |
| Home School: | East Carolina University |
| Visitor Record: | 8 - 4 |
| Visitor Conference: | Big East |
| Home Record: | 7 - 5 |
| Home Conference: | C-USA |
| Visitor Coach: | Jim Leavitt |
| Home Coach: | Skip Holtz |
| Visitor 1Q: | 14 |
| Visitor 2Q: | 10 |
| Visitor 3Q: | 0 |
| Visitor 4Q: | 0 |
| Home 1Q: | 7 |
| Home 2Q: | 0 |
| Home 3Q: | 0 |
| Home 4Q: | 0 |
| Date Game Played: | December 23 |
| Stadium: | Legion Field |
| City: | Birmingham, Alabama |
| Mvp: | Benjamin Williams (USF) |
| Referee: | Rick Doan (Sun Belt) |
| Attendance: | 32,023[1] |
| Payout: | 300,000 per team[2] |
| Us Network: | ESPN2 |
| Us Announcers Link: | List of announcers of major college bowl games |
| Us Announcers: | Gary Thorne (play-by-play); Andre Ware (analysis); Todd Harris (sidelines) |
| First Game Ever Played: | Yes |
The 2006 PapaJohns.com Bowl was the inaugural postseason college football match of the game, between the South Florida Bulls and the East Carolina Pirates at Legion Field in Birmingham, Alabama. The University of South Florida represented the Big East Conference and East Carolina University represented Conference USA. The game resulted in a 24 - 7 South Florida victory.
In the inaugural game, South Florida's Benjamin Williams scored the game's first points just over ninety seconds into the game as one of his two touchdowns on the day, and earned the game's MVP honors. Notably, South Florida had previously been a member of C-USA. Moreover, East Carolina's then head coach Skip Holtz, would later become USF head coach Jim Leavitt's successor following the 2009 season.