| Year: | 2006 |
| Team: | Ole Miss Rebels |
| Sport: | football |
| Conference: | Southeastern Conference |
| Division: | Western Division |
| Short Conf: | SEC |
| Record: | 4–8 |
| Conf Record: | 2–6 |
| Head Coach: | Ed Orgeron |
| Hc Year: | 2nd |
| Off Coach: | Dan Werner |
| Oc Year: | 1st |
| Off Scheme: | Spread |
| Def Scheme: | 4–3 |
| Captain: | Andrew Wicker |
| Captain2: | Patrick Willis |
| Stadium: | Vaught–Hemingway Stadium |
The 2006 Ole Miss Rebels football team represented the University of Mississippi as a member of the Western Division of the Southeastern Conference (SEC) during the 2006 NCAA Division I FBS football season. Led by second-year head coach Ed Orgeron, the Rebels compiled an overall record of 4–8 with a mark of 2–6 in conference play, tying of fourth place in the SEC's Western Division. Ole Miss played home games at Vaught–Hemingway Stadium in Oxford, Mississippi.