| Mode: | football |
| Year: | 2006 |
| Team: | Oklahoma State Cowboys |
| Conference: | Big 12 Conference |
| Division: | South Division |
| Short Conf: | Big 12 |
| Record: | 7 - 6 |
| Conf Record: | 3 - 5 |
| Head Coach: | Mike Gundy |
| Hc Year: | 2nd |
| Off Coach: | Larry Fedora |
| Oc Year: | 2nd |
| Def Coach: | Vance Bedford |
| Dc Year: | 2nd |
| Off Scheme: | Spread |
| Def Scheme: | 4–3 |
| Stadium: | Boone Pickens Stadium |
| Champion: | Independence Bowl champion |
| Bowl: | Independence Bowl |
| Bowl Result: | W 34 - 31 vs. Alabama |
The 2006 Oklahoma State Cowboys football team represented Oklahoma State University during the 2006 NCAA Division I FBS football season. They participated as members of the Big 12 Conference in the South Division. They played their home games at Boone Pickens Stadium in Stillwater, Oklahoma. They were coached by head coach Mike Gundy.