| Champ: |  James Blake |
| Runner: |  Igor Andreev |
| Score: | 6–2, 3–6, 7–6(7–3) |
| Draw: | 32 |
| Seeds: | 8 |
| Main Name: | Sydney International |
See main article: 2006 Medibank International.
Lleyton Hewitt was the defending champion, but lost in the quarterfinals to Andreas Seppi.
James Blake won in the final 6–2, 3–6, 7–6(7–3) against Igor Andreev.