| Year: | 2006 |
| Team: | Iowa State Cyclones |
| Conference: | Big 12 Conference |
| Division: | North Division |
| Short Conf: | Big 12 |
| Record: | 4–8 |
| Conf Record: | 1–7 |
| Hc Year: | 12th |
| Oc Year: | 3rd |
| Dc Year: | 11th |
| Stadium: | Jack Trice Stadium |
The 2006 Iowa State Cyclones football team represented Iowa State University during the 2006 NCAA Division I FBS football season. They played their home games at Jack Trice Stadium in Ames, Iowa. They participated as members of the Big 12 Conference in the North Division. They were coached by head coach Dan McCarney, who was in his final season as head coach of the Cyclones.