The 2006 Honda Grand Prix of St. Petersburg was the second round of the 2006 IndyCar Series season, held on April 2, 2006 on the Streets of St. Petersburg city track and covered by ESPN. Dario Franchitti won the pole, but was knocked out early due to mechanical failure. The race was won by Helio Castroneves, finishing under the yellow flag after Tomas Scheckter and Buddy Rice hit the barrier with 4 laps to go.
| Pos | Nat | Name | Team | Qual Time | Best Lap | Laps | |
|---|---|---|---|---|---|---|---|
| 1 | Dario Franchitti | Andretti Green Racing | 1:02.2753 | 5 | 6 | ||
| 2 | Scott Dixon | Chip Ganassi Racing | 1:02.5951 | 4 | 7 | ||
| 3 |  | Tony Kanaan | Andretti Green Racing | 1:02.6127 | 7 | 11 | |
| 4 |  | Sam Hornish Jr. | Team Penske | 1:02.6758 | 3 | 5 | |
| 5 | | Hélio Castroneves | Team Penske | 1:02.7482 | 4 | 8 | |
| 6 | | Bryan Herta | Andretti Green Racing | 1:02.8774 | 6 | 7 | |
| 7 | | Buddy Rice | Rahal Letterman Racing Team | 1:03.5648 | 1 | 1 | |
| 8 |  | Tomas Scheckter | Vision Racing | 1:03.7143 | 1 | 1 | |
| 9 |  | Kosuke Matsuura | Super Aguri Fernandez Racing | 1:03.8033 | 1 | 1 | |
| 10 | | Marco Andretti | Andretti Green Racing | 1:03.8853 | 1 | 1 | |
| 11 | | Roberto Moreno | Vision Racing | 1:03.9455 | 1 | 1 | |
| 12 | | Vítor Meira | Panther Racing | 1:04.0206 | 1 | 1 | |
| 13 | Dan Wheldon | Chip Ganassi Racing | 1:04.0267 | 1 | 1 | ||
| 14 | | Danica Patrick | Rahal Letterman Racing Team | 1:04.4436 | 1 | 1 | |
| 15 | | Scott Sharp | Super Aguri Fernandez Racing | 1:04.8588 | 1 | 1 | |
| 16 | | Felipe Giaffone | A. J. Foyt Enterprises | 1:05.3845 | 1 | 1 | |
| 17 | | Eddie Cheever Jr. | Cheever Racing | 1:05.5475 | 1 | 1 | |
| 18 | | Buddy Lazier | Dreyer & Reinbold Racing | 1:06.2425 | 1 | 1 | |
| 19 | | P. J. Chesson | Hemelgarn Racing | 1:08.8266 | 1 | 1 |