| Year: | 2006 |
| Team: | Grambling State Tigers |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Short Conf: | SWAC |
| Division: | West Division |
| Record: | 3–8 |
| Conf Record: | 3–6 |
| Head Coach: | Melvin Spears |
| Hc Year: | 3rd |
| Stadium: | Eddie G. Robinson Memorial Stadium |
The 2006 Grambling State Tigers football team represented Grambling State University as a member of the Southwestern Athletic Conference (SWAC) during the 2006 NCAA Division I FCS football season. Led by third-year head coach Melvin Spears, the Tigers compiled an overall record of 3–8 and a mark of 3–6 in conference play, and finished tied for third in the SWAC West Division.