See main article: 2006 Generali Ladies Linz.
Nadia Petrova was the defending champion, but lost in the final to Maria Sharapova 5–7, 2–6.
This was the final singles career of former World No. 3 Mary Pierce, who had retired in the second set where she was leading 6–5, due to sustaining a knee injury.
The top four seeds received a bye into the second round.