See main article: 2006 French Open.
Defending champion Justine Henin-Hardenne defeated Svetlana Kuznetsova in the final, 6–4, 6–4 to win the women's singles tennis title at the 2006 French Open. It was her third French Open title and fifth major title overall. She won the title without losing a set during the tournament, and without facing a tiebreak in any set.
This was the first French Open main draw appearance for future champion and world No. 2 Li Na, who lost in the third round to Svetlana Kuznetsova.
See main article: article and 2006 French Open – Women's singles qualifying.
| Category |  Henin-Hardenne |  Kuznetsova | |
|---|---|---|---|
| 1st serve % | 33/65 (51%) | 48/68 (71%) | |
| 1st serve points won | 25 of 33 = 76% | 29 of 48 = 60% | |
| 2nd serve points won | 14 of 32 = 44% | 9 of 20 = 45% | |
| Total service points won | 39 of 65 = 60.00% | 38 of 68 = 55.88% | |
| Aces | 4 | 0 | |
| Double faults | 3 | 3 | |
| Winners | 12 | 17 | |
| Unforced errors | 30 | 35 | |
| Net points won | 5 of 5 = 100% | 11 of 13 = 85% | |
| Break points converted | 4 of 7 = 57% | 2 of 2 = 50% | |
| Return points won | 30 of 68 = 44% | 26 of 65 = 40% | |
| Total points won | bgcolor=98FB989 | 69 | 54 |
| Source | |||