| Mode: | football |
| Year: | 2006 |
| Team: | East Carolina Pirates |
| Conference: | Conference USA |
| Division: | East |
| Short Conf: | C-USA |
| Record: | 7–6 |
| Conf Record: | 5–3 |
| Head Coach: | Skip Holtz |
| Hc Year: | 2nd |
| Off Coach: | Steve Shankweiler |
| Oc Year: | 2nd |
| Def Coach: | Greg Hudson |
| Dc Year: | 2nd |
| Off Scheme: | Multiple |
| Def Scheme: | 4–3 |
| Stadium: | Dowdy–Ficklen Stadium |
| Bowl: | PapaJohns.com Bowl |
| Bowl Result: | L 7–24 vs. South Florida |
The 2006 East Carolina Pirates football team was an American football team that represented East Carolina University as a member of Conference USA during the 2006 NCAA Division I-A football season. In their second season under head coach Skip Holtz, the team compiled a 7–6 record and were defeated by South Florida in the PapaJohns.com Bowl.[1]