The following are the winners of the 6th annual ENnie Awards, held in 2006:[1]
| Category | Gold Winner | Silver Winner | |
|---|---|---|---|
| Best Art, Cover | Monte Cook's Arcana Evolved: Spell Treasury (Malhavoc Press) | Mastermind's Manual (Green Ronin Publishing) | |
| Best Art, Interior | Legend of the Five Rings Third Edition (Alderac Entertainment Group) | Mastermind's Manual (Green Ronin Publishing) | |
| Best Cartography | Dragonlance: Tasslehoff's Map Pouch: The War of the Lance (Sovereign Press) | The Shackled City Adventure Path (Paizo Publishing) | |
| Best Production Values | Serenity Role Playing Game (Margaret Weis Productions) | A Game of Thrones (Guardians of Order) | |
| Best Writing | (White Wolf Publishing) | Pulp Hero (Hero Games) | |
| Best Rules | Shadowrun 4th Edition (FanPro) | Mutants & Masterminds Second Edition (Green Ronin Publishing) | |
| Best Adventure | The Shackled City Adventure Path (Paizo Publishing) | 1 on 1 Adventures #6.66: The Pleasure Prison of the B'thuvian Demon Whore (Expeditious Retreat Press) | |
| Best Adversary/Monster Product | Tome of Horrors 3 (Necromancer Games) | Iron Heroes Bestiary (Malhavoc Press) | |
| Best Campaign Setting/Setting Supplement | The Shackled City Adventure Path (Paizo Publishing) | Freedom City (Green Ronin Publishing) | |
| Best Supplement | Dragon Compendium Vol. 1 (Paizo Publishing) | Monte Cook's Arcana Evolved: Spell Treasury (Malhavoc Press) | |
| Best Aid or Accessory | Flip-Mat (Steel Sqwire) | The 13th Hour (Midnight Syndicate Soundtrack) | |
| Best Free Product or Web Enhancement | Age of Worms Overload (Paizo Publishing) | Mage the Awakening Demo (White Wolf Publishing) | |
| Best Electronic Book: Sponsored by RPGNow.com | Baba Yaga: The First Setting in Rassiya (Dog Soul Publishing) | Truth & Justice (Atomic Sock Monkey Press) | |
| Best Game | Mutants & Masterminds, 2e (Green Ronin Publishing) | A Game of Thrones (Guardians of Order) | |
| Best d20/d20 OGL Product | Mutants & Masterminds Second Edition (Green Ronin Publishing) | A Game of Thrones (Guardians of Order) | |
| Best Product | Shadowrun 4th Edition (FanPro) | Mutants & Masterminds Second Edition (Green Ronin Publishing) | |
| Best Fan Site | www.yog-sothoth.com | www.farlandworld.com | |
| Fan's Choice for Best Publisher | Green Ronin | Wizards of the Coast | |
| The Grognard Award (for companies that represent older gaming traditions) | Necromancer Games | Goodman Games | |
| Innovation Awards | Dread, The Impossible Dream | Truth and Justice, Atomic Sock Monkey Press |