| Year: | 2006 |
| Team: | Duke Blue Devils |
| Sport: | football |
| Conference: | Atlantic Coast Conference |
| Division: | Coastal Division |
| Short Conf: | ACC |
| Record: | 0–12 |
| Conf Record: | 0–8 |
| Head Coach: | Ted Roof |
| Hc Year: | 3rd |
| Off Coach: | Bill O'Brien |
| Off Scheme: | Pro-style |
| Oc Year: | 2nd |
| Codef Coach1: | Scott Brown |
| Codc1 Year: | 3rd |
| Codef Coach2: | Jerry Azzinaro |
| Codc2 Year: | 3rd |
| Def Scheme: | Multiple 4–3 |
| Mvp: | John Talley |
| Captain: | Casey Camero, Eli Nichols, John Talley |
| Stadium: | Wallace Wade Stadium |
The 2006 Duke Blue Devils football team represented the Duke University in the 2006 NCAA Division I FBS football season. The team was led by head coach Ted Roof. They played their home games at Wallace Wade Stadium in Durham, North Carolina. Duke finished the season with a record of 0–12.[1]